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Sickle Cell Anemia News
June 17, 2019

Top Headlines
 

Early Clinical Trial Data Show Gene Therapy Reversing Sickle Cell Anemia

After over a decade of preclinical research and development, a new gene therapy treatment for sickle cell anemia (SCA) is reversing disease symptoms in two adults and showing early potential for ... read more

Understanding the Berlin Patient's Unexpected Cure of HIV

Researchers have a new way to understand the much-studied Berlin patient's unexpected cure from HIV and improve outcomes of stem cell transplants for patients with other blood-related diseases such ... read more

First Patient Cured of Rare Blood Disorder

Using a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant, physicians have documented the first cure of an adult patient with congenital ... read more

Step Toward Gene Therapy for Sickle Cell Disease

A gene-editing tool known as CRISPR has been used to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the ... read more
Latest Headlines
updated 1:46pm EDT

Earlier Headlines
 

New Method to Rapidly, Reliably Monitor Sickle Cell Disease

Researchers have developed a rapid and reliable new method to continuously monitor sickle cell disease using a microfluidics-based electrical impedance sensor. This novel technology can characterize ... read more

To Be or Not to Be a White Blood Cell, That Is the Question

Japanese scientists have revealed a biological 'switch' that influences whether an immature blood cell would develop into a red blood cell or a subtype of white blood cell called myeloid ... read more

DNA Repair After CRISPR Cutting Not at All What People Thought

Scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. It acts as a ... read more

Treatments for Cancer and Sickle Cell Disease Deplete Germ Cells in Young Boys

Scientists have discovered that some treatments for cancer and sickle cell disease can destroy the germ cells that go on to develop into sperm in the testes of young boys. In some pre-pubescent boys, ... read more

Enzyme Identified as Possible Novel Drug Target for Sickle Cell Disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell ... read more

Genome-Editing Tool Could Increase Cancer Risk

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer, according to a new study. Researchers say that more studies are required in ... read more

'Incompatible' Donor Stem Cells Cure Adult Sickle Cell Patients

Doctors have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be ... read more

Healthy Red Blood Cells Owe Their Shape to Muscle-Like Structures

Researchers report that a protein called myosin IIA contracts to give red blood cells their distinctive shape. The findings could shed light on sickle cell diseases and other disorders where red ... read more

Solution to 50-Year-Old Mystery Could Lead to Gene Therapy for Common Blood Disorders

In a landmark study that could lead to new therapies for sickle cell anemia and other blood disorders, researchers have used CRISPR gene editing to introduce beneficial natural mutations into blood ... read more

A Breakthrough in Our Understanding of How Red Blood Cells Develop

For the first time, cellular machines called ribosomes -- which create proteins in every cell of the body -- have been linked to blood stem cell differentiation. The findings have revealed a ... read more

Progress in Pursuit of Sickle Cell Cure

Bioengineers use gene editing to correct the mutation responsible for sickle cell disease in up to 40 percent of patients' cells used for lab ... read more

Relatively Unknown Gene Linked to Early Emergence of Blood Diseases

Researchers have discovered the contribution of a specific gene in the proper development of blood cells that give rise to hematopoietic stem cells. The findings identify a potential target for the ... read more

'Negative Emotions' Linked to Higher Rates of Opioid Use in Sickle Cell Disease

A link has been foundbetween negative emotions, such as sadness and anxiety, and higher opioid use in people with sickle cell disease whose pain levels were self-reported as relatively low. These ... read more

Blueprint to Reduce Wasteful Blood Transfusions

By analyzing data from randomized clinical trials comparing blood transfusion approaches, experts endorse recommendations for blood transfusions that reduce blood use to improve patient safety and ... read more

Out of Balance: Gut Bacterial Makeup May Exacerbate Pain in Sickle Cell Disease

An overabundance of the bacteria Veillonella in the digestive tract may increase pain in patients with sickle cell disease ... read more

New Machine Learning System Can Automatically Identify Shapes of Red Blood Cells

Using a computational approach known as deep learning, scientists have developed a new system to classify the shapes of red blood cells in a patient's blood. The findings, published in PLOS ... read more

Sickle Cell Anemia Treatment Does Not Increase Malaria Risk in Africa

The drug hydroxyurea does not appear to increase the risk of malaria infection in patients with sickle cell anemia who live in malaria-endemic regions, according to a ... read more

New Portable Blood Analyzer Could Improve Anemia Detection Worldwide

To reduce the burden of anemia, health officials need a better picture of the disease's global impact, an understanding made viable by a portable and affordable way to analyze blood. Researchers ... read more

Metabolism Directly Impacts the Odds of Developing Malaria

Researchers have found that the host's susceptibility to develop malaria depends on his or her metabolic state, which can be easily manipulated through external stimuli such as dietary ... read more

Computer Models Provide New Understanding of Sickle Cell Disease

Simulations developed by mathematicians provide new details of how sickle cell disease manifests inside red blood cells, which could help in developing new ... read more

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