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Lymphoma News
May 19, 2019

Top Headlines
 

CLL Patient Goes Into Remission Thanks to Single CAR T Cell

Researchers say a patient treated for chronic lymphocytic leukemia (CLL) in 2013 went into remission because of a single CAR T cell and the cells it produced as it multiplied, and has stayed cancer ... read more

Cancer 'Vaccine' Eliminates Tumors in Mice

Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a ... read more

Complete Remission of Brain Metastasis of Difficult-to-Treat Tumor

Medical researchers report a remarkable treatment response in a patient participating in a clinical trial of a novel immune-system-based cancer ... read more

Patients With Advanced Lymphoma in Remission After T-Cell Therapy

Data has been released from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy. CAR T ... read more
Latest Headlines
updated 4:16am EDT

Earlier Headlines
 

Why Lymphoma Patients May Become Resistant to Specific Therapy

Researchers have discovered a mechanism of drug resistance to Venetoclax®, also known as ABT-199, a BCL-2 targeting drug commonly used to treat chronic lymphocytic leukemia and acute myeloid ... read more

Why Hodgkin's Lymphoma Cells Grow Uncontrollably

Although classical Hodgkin's lymphoma is generally easily treatable today, many aspects of the disease still remain a mystery. A team has now identified an important signaling molecule in the ... read more

Radiotherapy After Chemo May Improve Survival in Patients With Advanced Hodgkin's Lymphoma

Patients with advanced Hodgkin's lymphoma who have large tumors at the time of diagnosis may benefit from radiotherapy after chemotherapy even when all traces of the cancer appear to have ... read more

Researchers Discover How Tumor-Killing Immune Cells Attack Lymphomas in Living Mice

Researchers reveal that chimeric antigen receptor (CAR) T cells can induce tumor regression by directly targeting and killing cancer cells, uncovering new details of how these immune cells work and ... read more

A New Method to Diagnose Cancer Cells Inside Lymph Nodes

The vast majority of cancer deaths occur due to the spread of cancer from one organ to another, which can happen either through the blood or the lymphatic system. However, it can be tricky to detect ... read more

Killer Blows? Knockout Study of Pair of Mouse MicroRNA Provides Cancer Insight

Researchers used knockout mouse models created by gene editing to reveal that the miRNA miR-146b, like miR-146a, is involved in the development of cancers, with them having similar but not identical ... read more

New Strategies May Improve CAR-T Cell Therapy

Researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy (CAR-T cell therapy) in treating ... read more

Genetically Engineered Immune Cells Show Promise for Fighting Relapsed Blood Cancer

Researchers are presenting preliminary results from a clinical study of an investigational cellular immunotherapy for Hodgkin lymphoma and non-Hodgkin lymphoma expressing the CD30 protein ... read more

Promising New Target for Immunotherapy

Researchers have shed new light on a molecule called TIM-3 that might play a key role in the regulation of the immune ... read more

New Model Mimics Human Tumors for Accurate Testing of Cancer Drugs

Researchers have genetically engineered a new laboratory model that enables accurate testing of anti-cancer drugs by mimicking the complexity of human cancers. Using this advanced model, researchers ... read more

Supercharged Natural Killer Cells May Hold Promise for Cancer

New research suggests that a type of 'supercharged' immune cell could be mass-produced to help fight ... read more

'Liquid Biopsy' Predicts Lymphoma Therapy Success Within Days

A blood test can predict which patients with a type of cancer called diffuse large B cell lymphoma are likely to respond positively to initial therapy and which are likely to need more aggressive ... read more

Long Periods of Viral Suppression Shown to Reduce Cancer Risk in Aging HIV Population

Early, sustained antiretroviral therapy (ART), which results in long-term viral suppression, helps to prevent AIDS-defining cancers and also non-AIDS-defining cancers, to a lesser degree. However, ... read more

Breaking Through a Tumor's Defenses

Researchers have shown that some tumors use not one but two levels of protection against the immune system. Knocking out one level boosted the protective effects of the second and vice versa. The ... read more

Molecular Culprit Behind Virus-Mediated Chronic Inflammation and Cancers Identified

Within cells infected by Kaposi sarcoma herpesvirus (KSHV), the human protein CADM1 interacts with viral proteins to promote chronic inflammation, which plays a major role in the development of ... read more

Attacking Lymphoma at the Source

The efficacy of target specific therapies in lymphoma is limited to subgroups of patients. Scientists have identified a mechanism that confers resistance against a common therapy for lymphoma. They ... read more

Epigenetics Therapy Shows Promise in Patients With Lymphoma

New compounds targeting epigenetics have shown remarkable early activity in patients with lymphoma, according to new ... read more

T-Cells Engineered to Outsmart Tumors Induce Clinical Responses in Relapsed Hodgkin Lymphoma

A research team has validated a way to outfox tumors. They engineered T-cells, essential players in the body's own immune system, to strip tumors of their self-preservation skill and were able ... read more

Simple Test Can Diagnose Two Cancer Types

A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a new ... read more

Global CAR T Therapy Trial Shows High Rates of Durable Remission for Non-Hodgkin's Lymphoma

In a pair of clinical trials stretching from Philadelphia to Tokyo, the chimeric antigen receptor (CAR) T cell therapy Kymriah™ (formerly known as CTL019) demonstrated long-lasting remissions in ... read more

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