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Cystic Fibrosis News
May 21, 2019

Top Headlines
 

Potential Cystic Fibrosis Treatment Uses 'Molecular Prosthetic' for Missing Lung Protein

An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing or dysfunctional in the lungs of ... read more

New Lung Cell Type Discovered

Two research teams report the discovery of a new, rare type of cell in the human airway. These cells appear to be the primary source of activity of the CFTR gene, mutations to which cause cystic ... read more

Protein Structure Could Unlock New Treatments for Cystic Fibrosis

Biochemists have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to ... read more

Potential New Treatment to Treat and Stop Progression of Cystic Fibrosis

Researchers have discovered a potential new drug to treat and stop the progression of cystic fibrosis. Thymosin ?1 (T?1) is a novel therapeutic single molecule-based therapy that not only corrects ... read more
Latest Headlines
updated 2:46am EDT

Earlier Headlines
 

Blood Test Could Lead to Cystic Fibrosis Treatment Tailored to Each Patient

Researchers have used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis. These patterns of gene expression ultimately could help ... read more

For CF Lung Infections, How Well Antibiotics Work May Be Affected by pH, Oxygen

Researchers report that tweaking factors in a cystic fibrosis lung model, such as pH balance and oxygen, helped eradicate pathogenic bacteria while minimizing risks of antibiotic resistance and ... read more

Cystic Fibrosis Impacts Growth in the Womb, Research Shows

New research has shown that babies with cystic fibrosis are born weighing less than babies without the condition, even allowing that they are more likely to be born ... read more

Technique May Improve Lung Delivery of Bacteria-Killing Phage

A new delivery system for bacteriophages -- viruses that selectively attack harmful bacteria -- could help give doctors a new way to battle lung infections that threaten older patients and people ... read more

Supplemental Antioxidants May Reduce Exacerbations in Cystic Fibrosis

An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis (CF), according to new ... read more

Cystic Fibrosis Bacterial Burden Begins During First Years of Life

Cystic fibrosis shortens life by making the lungs prone to repeated bacterial infections and inflammation. Researchers have now shown for the first time that the lungs' bacterial population ... read more

Treatment Strategies for Multidrug-Resistant Chronic Infections

A new study finds that antibiotic treatment of chronic infections can be optimized by targeting vulnerabilities of antibiotic-resistant pathogens paving the way for more effective treatment ... read more

Defect in Zinc Supply Mechanism Affects Pathology of Intractable Pulmonary Diseases

Researchers revealed that abnormal delivery of zinc to lung cells contributes to obstructive pulmonary diseases. They further showed that mRNA splicing abnormalities are involved in the detailed ... read more

Cystic Fibrosis: Discovery of a Key Molecule for Improving Treatments

Researchers identify a promising avenue for improving treatments for people with cystic fibrosis. They found that adding molecules called quorum-sensing inhibitors to current drugs not only reduces ... read more

Health of People With Cystic Fibrosis Shows Positive Trends in US and Canada

Research comparing cystic fibrosis patients in the United States and Canada showed that, although patients' nutritional status and lung function improved in both countries from 1990 to 2013, the ... read more

New Simple Test Could Help Cystic Fibrosis Patients Find Best Treatment

While new CF drugs are life-changing for some patients, they don't work for everyone. Now, researchers present a simple test that aims to predict which treatment is most likely to work for each ... read more

New Test to Measure the Effectiveness of CF Drugs

A new laboratory model has been created to measure and compare the responses of CF and normal airway cells to CF-related infectious/inflammatory ... read more

Some People With Cystic Fibrosis Might Live Longer Because of Genetic Mutations

Genetic mutations to an 'epithelial sodium pathway' could protect against cystic fibrosis and its debilitating effects on the lungs, a new study ... read more

The Microbial Anatomy of an Organ

The first 3-D spatial visualization tool has been developed for mapping 'omics' data onto whole organs. The tool helps researchers and clinicians understand the effects of chemicals, such ... read more

Microbiologists Uncover Clues to Clustering of Lethal Bacteria in CF Patients' Lungs

Microbiologists are adding to body of knowledge of biofilm formation with the ultimate goal of finding better ways to disrupt that formation, leading to improved treatments for the chronic pneumonia ... read more

Predatory Bacteria Found in Study of Cystic Fibrosis Patients' Lung Microbiome

Cystic fibrosis patients have a wide variety of bacteria in their lungs, including two 'predators' not detected before, according to a new ... read more

Chronic Bronchitis: New Insights Could Lead to First Diagnostic Test, Better Treatments

Researchers describe how the concentration of mucins -- the proteins that make mucus thick -- is abnormally high in chronic bronchitis and that high mucin concentrations are associated with disease ... read more

Cystic Fibrosis Alters the Structure of Mucus in Airways

Cystic fibrosis (CF) alters the structure of mucus produced in airway passages. In pigs affected by CF, mucus strands (made of MUC5B protein) are more tangled than normal, and the sheets of mucus ... read more

Bacteria from Cystic Fibrosis Patient Could Help Thwart Antibiotic-Resistant TB

The number of drug-resistant tuberculosis (TB) cases is rising globally. But a newly discovered natural antibiotic -- produced by bacteria from the lung infection in a cystic fibrosis patient -- ... read more

Cystic Fibrosis Study Offers New Understanding of Silent Changes in Genes

Researchers studying the root cause of cystic fibrosis have made a major advance in our understanding of silent gene changes with implications for the complexity of cystic ... read more

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