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Amyotrophic Lateral Sclerosis News
June 24, 2019

Top Headlines
 

Synthetic Speech Generated from Brain Recordings

A state-of-the-art brain-machine interface created by neuroscientists can generate natural-sounding synthetic speech by using brain activity to control a virtual vocal tract -- an anatomically ... read more

How the Gut Influences Neurologic Disease

A study sheds new light on the connection between the gut and the brain, untangling the complex interplay that allows the byproducts of microorganisms living in the gut to influence the progression ... read more

Discovery of a Promising Medication for Amyotrophic Lateral Sclerosis (ALS)

A drug used to treat schizophrenia has the potential to slow the progression of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which there is currently no effective cure. ... read more

Scientists Prevent Neurodegeneration-Associated Protein Clumping in Lab Study

By artificially exposing FUS proteins to the natural process of phosphorylation, researchers were able to prevent them from forming the harmful ... read more
Latest Headlines
updated 11:16pm EDT

Earlier Headlines
 

ALS Research Reveals New Treatment Approach

New research on amyotrophic lateral sclerosis (AML) has revealed that a protein called membralin plays a key role in the disease process. The study suggests that membralin-boosting gene therapy is a ... read more

Neurotoxic Cyanotoxins Prevalent in Eastern Australian Freshwater Systems

The presence of an amino acid, BMAA, produced by blue-green algae (cyanobacteria) and thought to be associated with a higher incidence of neurodegenerative disease, has been confirmed in eastern ... read more

Potential Therapeutic Target for Amyotrophic Lateral Sclerosis

New research has revealed that the protein TDP-43 regulates a gene called Stathmin2 (STMN2). STMN2 shows promise as a therapeutic target and could be the first biomarker ALS, which is extremely ... read more

Biologists Identify Promising Drug for ALS Treatment

Scientists have found a new application for an existing drug, with potential to slow progression of amyotrophic lateral ... read more

Genetic Cause of ALS and Frontotemporal Dementia Blocked by RNA-Binding Compound

A new compound blocks the most common genetic cause of familial ALS and frontotemporal dementia. Results suggest that the target currently being pursued by many research groups may not actually be ... read more

Two-Step Control Mechanism Identified in Mouse Stem Cells

Scientists identified two distinct control mechanisms in the developmental transition of undifferentiated stem cells into healthy brain cells. This fundamental research using mice may inform ... read more

Cannabis-Based Drug in Combination With Other Anti-Spasticity

Oral spray containing two compounds derived from the cannabis plant reduced spasticity compared with placebo in patients already taking anti-spasticity ... read more

New Method for Studying ALS More Effectively

The neurodegenerative disease ALS causes motor neuron death and paralysis. However, long before the cells die, they lose contact with the muscles as their axons atrophy. Researchers have now devised ... read more

Sensory Neurons Can Be Used to Discover Therapies for ALS

Scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis -- also known as ALS or Lou Gehrig's ... read more

Promising Proteins for Diagnostic, Prognostic Use in ALS

Researchers have identified proteins that may be useful in both earlier diagnosis of Amyotrophic Lateral Sclerosis (ALS) and in more accurate disease ... read more

Regulating Microglial Activity May Reduce Inflammation in Neurodegenerative Diseases

A group of investigators is proposing that targeting immune checkpoints -- molecules that regulate the activity of the immune system -- in immune cells called microglia could reduce the inflammatory ... read more

Neuron Death in ALS More Complex Than Previously Thought

Researchers have discovered that two different kinds of motor neurons that die in people with ALS may die in different ways -- an important insight for understanding the disease and, eventually, ... read more

Finding That Links ALS/ataxia to Cellular Stress Opens New Approaches for Treatment

Scientists report for the first time that a protein, called Staufen1, accumulates in cells of patients suffering from degenerative ataxia or amyotrophic lateral sclerosis (ALS), also known as Lou ... read more

New Mechanism for How ALS Disease Evolves

Researchers have found a mechanism for how amyotrophic lateral sclerosis (ALS) evolves. The discovery concerns how proteins with a defect structure spread the deformation to other ... read more

Molecular Link Between Aging and Neurodegeneration

Researchers have discovered a molecular link between aging and a major genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia, two related neurodegenerative diseases with ... read more

Rogue Proteins May Underlie Some ALS and Frontotemporal Dementia Cases

Some forms of ALS and frontotemporal dementia share a common loss of functioning of RNA-binding proteins that regulate gene expression, says a new ... read more

Drugs in Development for Cancer May Also Fight Brain Diseases, Including ALS

A class of cancer drugs called PARP inhibitors could be useful for treating and preventing brain disorders, including ALS (Lou Gehrig's disease) and some forms of frontotemporal degeneration, by ... read more

New Stem Cell Model Can Be Used to Test Treatments for a Rare Nervous System Disorder

A new stem cell model has been developed to assess possible treatments for a rare nervous system disorder that is in the same disease group as Alzheimer's disease, Parkinson's disease and ... read more

Dr. Jekyll, Mr. Hyde: Healing Mesenchymal Cells Morph and Destroy Muscles in Models of Spinal Cord Injury, ALS and Spinal Muscular Atrophy

Scientists have discovered a new disease-specific role in FAP cells in the development of muscle tissue wasting, indicating a potential new avenue for treating motor neuron diseases including spinal ... read more

Next Generation ALS Drug Silences Inherited Form of the Disease in Animal Models

Researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results ... read more

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